Research Progress of Hedyotis diffusa.docVIP

 PAGE \* MERGEFORMAT 11 Research Progress of Hedyotis diffusa [Keywords:] white flowers Keywords: Hedyotis diffusa; chemical composition; pharmacological effect; clinical application of This product is Rubiaceae annual herbs Hedyotis diffusa Hedyotis diffusaWilld. Of the whole plant, located in China’s Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Hubei, Hunan, Guangdong and southwest, the summer and autumn collection, cleaning, fresh or dried to use, cut into sections. Of flavor and a meridian Pickle, cold in nature. Owned by the stomach, large intestine, small intestine by [1]. 2 Functions and indications Convergence bleeding, heat detoxification, Lishi Tonglin, phlegm dampness. For hematemesis, hemoptysis, blood in the stool, enteritis, measles, pneumonia, jaundice, hepatitis, epilepsy, hold the spit Yongsheng; external governance of paddy fields, skin rashes, pimples, eczema, otitis media, trauma hemorrhage. 3 Chemical Composition 3.1 triterpenes oleanolic acid, ursolic acid, mountain ganzi ketone, isosorbide ganzi alcohol [2,3]. 3.2 steroid β -sitosterol, β sitosterol D glucose Gan, γ -sitosterol, stigmasterol [4]. 3.3 iridoid glycosides 6O quote Paederia p-coumaric acyl methyl ester, 6O-methoxy cinnamic methyl ester acyl Paederia, 6O glycosides Paederia ferulic acyl ester, such as car leaves grass glycosides. 3.4 Other anthraquinones 2-methyl 3-hydroxy-anthraquinone, 2-methyl 3-methoxy-anthraquinone, 4,4-dimethoxy group of wire acid [5], 4,4-dimethoxy between coca acid, 4,4-Dihydroxy between coca acid, 5-HT [6], 30 alkyl, soil angelica acid, 4-methyl putrescine, p-coumaric acid, peptide, ursolic acid [7], Fe, Mn, Al, Si, Ca, Ti and other elements [8]. It also contains alkaloids, cardiac glycosides, dimethyl ether derivatives. 4 Pharmacology 4.1 Anti-tumor effects in vitro model of acute lymphocyte, granulocyte cell type, mononuclear cell type, as well as chronic myeloid-type tumor cells with strong inhibition. Valsalva breathing apparatus with