Research Progress of realgar.docVIP

 PAGE \* MERGEFORMAT 2 Research Progress of realgar [Abstract] an overview of the chemical composition of realgar, processing technology, pharmacokinetics, pharmacological effects, clinical application and toxicity, and the preparation technology of realgar prospected. [Keywords:] realgar; chemical composition; processing technology; pharmacological effect; clinical application of Realgar is a commonly used Chinese medicine for external use within the government, one of the first income is contained in ‘Shen Nong Ben Cao Jing’, dating back thousands of years of history has been. Realgar, also known as Shi Huang, whose sexual Xin warm, bitter, toxic. The 2005 edition of ‘Chinese Pharmacopoeia’ closed set of proprietary Chinese medicines containing a total of 26 realgar, accounting for 4.6% of the total number of Narikata Pharmacopoeia [1]. Traditional medicine that realgar with detoxification, insecticide, dampness, phlegm, intercept of malaria and other functions. Since the 20th century, since the 50’s, the domestic doctor realgar-containing compound of preparation or unilateral for the treatment of blood system diseases, malignant diseases or solid tumors, the lymphatic system and achieved significant therapeutic effect, causing widespread concern. In this paper, the chemical composition of realgar, processing techniques, pharmacological mechanism of action, clinical applications and side effects are reviewed. A chemical composition The main chemical components of realgar As4S4 or As2S2, also contains a small amount of arsenic trioxide (As2O3) and arsenic pentoxide (As2O5). Over time, the discussion of the main component of realgar has not been interrupted, 2000 edition of ‘Chinese Pharmacopoeia’ provisions of the main ingredients of realgar As2S2, its content shall not be less than 90%. Leung Kwok-Gang et al [2] that the main components of realgar As4S4, only in the 550 ~ 800 ℃ when broken down into As2S2. Chen Xianping et al [3] the use of electron