Research Progress of mammalian selenoprotein.docVIP

 PAGE \* MERGEFORMAT 21 Research Progress of mammalian selenoprotein Abstract Selenium is a trace element essential to mammals and man. The biological function of selenium mainly in the form of selenoprotein expression. So far, have been cloned and determined cDNA sequence of selenoprotein mammals and 9 species, which are intracellular glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, gastrointestinal Valley PHGSH enzyme. Type Ⅰ iodide ronine 5 ‘deiodinase, selenoprotein P and selenoprotein W. The participation of selenium in selenoprotein into the protein molecules are identified through the selenocysteine-tRNA-specific mRNA in the UGA codon into selenocysteine Se-proteins. Keywords: selenium; selenium protein; biological function; expression and regulation Abstract Selenium is am essential trace element for animals and humans. Selenium exerts its biological function largely through selenoproteins. Up to now nine selenporoteins’ cDNAs have been cloned and sequenced, which are cellular glutathione peroxidase (cGPX), extracellular glutathine peroxidase (eGPX), phospholipid hydroperoxidase glutathione perxidase (PHGPX), gastrointestinal glutathione peroxidase (GPX-GI), type I iodothyronine5 ‘-deiondenase (ID Ⅰ ) type 2 iodothyronine5’deioninase (ID Ⅱ ), type Ⅲ iodothyronine5-deiodinase (ID Ⅲ ), selenoprotein p (SeP) and selenoprotein W. In all these selenoproteins Se is incorporated into the protein molecule via the selenocysteinyl-tRNA which recognizes the specific UGA codons in mRNA to insert selenocysteine into the primary structure of selenoproteins. Keywords: Selenium; Selenoprotein; Biological function; expression and regulation Selenium (Se) is a 1817 Swedish scholar Berzelius discovered the nature of the elements like sulfur. Until 1957, Schwarz and Foltz was confirmed that essential trace element Se is an animal. Selenium, and other human and animal growth, development and closely linked to the occurrence of the disease. S