Research the pathogenesis of Kawasaki disease.docVIP

 PAGE \* MERGEFORMAT 22 Research the pathogenesis of Kawasaki disease [Abstract] common diseases in children in recent years has become one of Kawasaki disease, pathological changes of the small arteries of systemic inflammation, often involving the heart, as children with acquired heart disease, one of the main reasons, and may become the adult ischemic heart disease risk factor. pathogenesis of Kawasaki disease is still not clear at present, this article reviews the recent research on the pathogenesis of Kawasaki disease status. [Keywords:] Kawasaki; pathogenesis; review literature Kawasaki disease (Kawasaki disease, KD) in 1967 by the Japanese Kawasaki rich first reported [1], has been called the mucocutaneous lymph node syndrome (MCLS), occurs in infants and children under 5 years old, has become in recent years in children with KD One disease, pathological changes of the small arteries of systemic vasculitis, the clinical features of fever, mucositis, rash, changes in cervical lymph nodes and extremities, including the heart attack early heart inflammation, coronary artery inflammation and inflammation, post- manifested as myocardial infarction and ischemic heart disease, acquired heart disease in children as the main reason, the incidence rate of more than rheumatic heart disease, and may become the adult ischemic heart disease risk factor. pathogenesis are not entirely clear at present KD , and this paper on the pathogenesis of KD status reviewed below. A super-antigen reaction Now widely recognized that the antigen is caused by KD exogenous antigens, mainly Staphylococcus aureus enterotoxin A ~ C, A group of streptococcal pyrogenic exotoxin A ~ C, toxic shock syndrome toxin (TSST). Some people were study found that streptococcal pyrogenic exotoxin A (SPE A) and streptococcal pyrogenic exotoxin C (SPE C) as a super-antigen activated T cells with a strong capacity [2]. superantigen with TCR, BCR antigen binding groove outer part of the comb