Right brain protective effect of naloxone.docVIP

Right brain protective effect of naloxone Abstract: Naloxone is through non-specific competitive receptor antagonist, for all are endogenous opioid peptide receptor antagonism. Of its high fat-soluble, through the blood - brain barrier. Keywords:: cerebral protective effect of naloxone antagonist Preface Baskin such reports since 1981 of naloxone can effectively reverse the neurological damage after stroke patients, the opioid receptor antagonist, and central nervous system damage of great importance is attached [1]. In severe stress, the body releases large amounts of endogenous opioid peptides can lead to decreased cerebral perfusion pressure, cerebral tissue ischemia and hypoxia and respiratory depression and disturbance of consciousness is mounting. The experimental results confirm that naloxone has a protective effect on nerve cells and can promote functional recovery of the nervous system and improve prognosis. Now neuroprotective effect of naloxone on the progress of relevant studies are summarized below. A Neuroprotective mechanism of naloxone reversal of 1.1 in brain tissue after traumatic brain injury of calcium ions and the increase of excitatory amino acids Intracellular and extracellular calcium ion balance disorder is ischemia-reperfusion brain injury in the pathogenesis of a key link, this view has become a consensus. Intracellular calcium ([Ca2] i) increase in both the consequences of brain damage, while a further dynamic factor beginning of brain damage, and even called [Ca2] i increase as ‘the final common pathway of cell death’. After the occurrence of cerebral ischemia due to adenosine triphosphate (ATP) generation gaps and membrane depolarization, leading to voltage-gated calcium channel opening, while the excitatory amino acids (EAA) is also a large number of extracellular accumulation, activation in the cell membrane of the affected body, so that receptor-gated calcium channel is also open, which resulted in two ways of extracellular calc