Restrictions on movements of right femur tibia physical properties bio-mechanical indicators and bone morphogenetic protein-2 expression in.docVIP

 PAGE \* MERGEFORMAT 6 Restrictions on movements of right femur tibia physical properties bio-mechanical indicators and bone morphogenetic protein-2 expression in [Abstract] Objective: This study compared the restrictions on movements of 4 wk in rats and normal control rats lower limb femur, tibia physical properties, including wet weight, ash mass, bone mineral content, bone mineral density, bio-mechanical indicators and bone morphogenetic protein-2 expression in quantitative changes, the purpose is to identify restrictions on movements of rats which adversely affect the lower limb growth. Methods: Leg  production in rat tail fixation restrictions on movements of the model, using DPX dual-energy X-ray absorptiometry measurement of rat left lateral lower limb bone mineral content and bone mineral density, with WD universal material testing machine femur 3 points bending test, a measurement of the femur of the failure strength, failure load, destroyed energy absorption and stiffness coefficient biomechanical indicators, using immunohistochemical staining and compare the gray-scale comparison of bone morphogenetic protein-2 expression changes. Results: The restrictions on movements of 4 wk, the rats were femur, tibia bone wet weight, ash mass, bone mineral content, bone mineral density, bio-mechanical indicators and the normal control group there is declining, and with bone formation are closely related to the expression of bone morphogenetic protein-2 were also down. Conclusion: The restrictions on movements of rats lower limb (femur, tibia) had a negative impact on growth, reflected in changes in physical properties of lower limb and bone inhibition of the formation of protein expression and so on. [Keywords:] exercise femur and tibia bone morphogenetic protein-2 0 Introduction Human bone development and growth affected by many factors, the movement is affecting bone growth and remodeling acquired an important factor in the role of mechanical signals on t