Removal of white blood cell transfusion can decrease transfusion reactions.doc

 PAGE \* MERGEFORMAT 4 Removal of white blood cell transfusion can decrease transfusion reactions [Abstract] white blood cells are the body’s natural defense system, an important part, but lost use of blood products containing white blood cells may produce many side effects, such as non-hemolytic febrile reactions, platelet transfusion, post-transfusion graft-versus-host disease and the possible spread of cell-associated virus. At present such reactions can be effective in preventing the occurrence of simple and easy method is to use the filter to remove white blood cells white blood cells blood products. [Keywords:] leukocyte filter; removal of white blood cell transfusion; transfusion reactions Clinical transfusion reactions occurred mainly due to transfusion of blood components containing white blood cells produce white blood cells system (HLA) antibodies, causing the same kinds of immune response, leading to fever and other clinical adverse symptoms, use of leukocyte filters the blood to filter out 99.9% of white blood cells, Most of platelets and micro-polymer, so that non-hemolytic febrile reactions were significantly reduced. One of the reasons for adverse transfusion reactions occur Because of the highly polymorphic HLA, and the current infusion of blood components to the majority of donor-recipient HLA matching between the no and easy to cause the recipient to produce HLA antibodies. Production of HLA antibodies in patients with transfusion frequency of roughly linear relationship, the more the number affected by the blood to produce antibodies greater the opportunity, the greater the likelihood of transfusion reaction occurs. Clinically, the most common reaction to a non-hemolytic febrile transfusion reactions, mainly because the victims body to produce antibodies of the white blood cells, once again encountered the blood components containing white blood cells when the recipient antibody and the occurrence of donor leukocyte kinds of imm