Risperidone in the treatment of schizophrenia gender differences in plasma concentration.doc

 PAGE \* MERGEFORMAT 9 Risperidone in the treatment of schizophrenia gender differences in plasma concentration [Abstract] Objective To explore risperidone in schizophrenia gender differences in plasma concentration. Methods 49 patients met the DSM-IV diagnostic criteria for schizophrenia were divided into two groups by sex, regular testing of blood drug concentration. Results with the same dose of risperidone (each 2mg / d for men and women in two groups, 2 weeks after detection of plasma concentrations there was a significant statistical significance P lt;0.05, adjusted by the dose (3mg Male Female 3.5mg, 6 weeks after again detected plasma concentration of risperidone, plasma concentrations of the two groups was no statistically significant, Pgt; 0.05. Conclusion The same dose of risperidone in the treatment of schizophrenia, plasma concentrations of the two groups are statistically significant detection, prompted with the same dose of risperidone in the treatment of schizophrenia, there are gender differences. [Keywords:] risperidone in schizophrenia gender differences in plasma concentration [Abstract] objective: The purpose is to explore for risperidone in schizophrenic patients blood concentration and efficacy of the gender gab.Methods: A total of 49 patients met with the criteria of DMS-IV for Schizophreria were assigned to Male and Female team, After two weeks and six weeks dose adjustments again risperidone plasma concertration detection and analysis of effects. Results: The same dose of risperidone for the treatment of two groups of men and women, two weeks after the detection of blood concentration, there are significant differences; P lt;0.05 Efficacy of the drug was no singificant statistical significance Pgt; 0.05, but there are obvious clinical significance.After 6 weeks after dose adjustments again risperidone plasma concertration detection and analysis of the effects, both Pgt; 0.05, there was no significant statistical significa