Sea squirts on the experimental diabetic rats non-enzymatic glycation of.docVIP

 PAGE \* MERGEFORMAT 12 Sea squirts on the experimental diabetic rats non-enzymatic glycation of [Abstract] Objective To confirm the validity of ascidian diabetes and to explore its mechanism. Methods production chain urinary streptozotocin diabetic rats by intraperitoneal injection, 1 w after checking their fasting blood glucose, blood glucose levels greater than 8.1 mmol / L of the rats were randomly divided into 3 groups: group of sea squirts, glibenclamide (positive control group, diabetic control group. Another 10 rats served as control group. continuous administration of 4 w after application to detect the tail vein blood glucose levels, plasma fructosamine and glycosylated Hb values #8203;#8203;and the pancreas, kidney and liver protein glycation value. Results streptozotocin injection blood glucose levels were significantly higher than the control group. continuous administration of sea squirts and 4 w after glibenclamide group, model control blood glucose was significantly higher than the control group, sea squirts and glibenclamide groups was significantly lower than the control group. plasma, red blood cells, liver, pancreas and kidneys was significantly lower than the glycosylated protein model control group. Conclusion ascidian obvious hypoglycemic effect of plasma proteins caused by high blood sugar and liver, kidney, pancreas protein non-enzymatic glycosylation significantly inhibited. [Keywords:] sea squirt blood animal protein glycosylation Abstract: Objective To confirm the effectiveness of ascidians on diabetes and to probe into its functional mechanism. Methods The mice were injected intraperitonealy with streptozotocin (STZ) to be used as experimental models of diabetic mice. Having been tested the fasting blood glucose after one week , the mice whose blood glucose were over 8.1mmol / L were divided into three groups randomly: ascidians group, Youjiangtang (positive control drug) group, diabete control group. Another ten mice were