Senile memory impairment and prefrontal function.docVIP

 PAGE \* MERGEFORMAT 23 Senile memory impairment and prefrontal function Keywords:: aged prefrontal cortex (PF) and memory impairment Frontal lobe brain development is the most advanced part of, which includes the primary motor area, pre-motor area and prefrontal cortex (prefrontal corte, PF), in which closely related to PF and cognitive function. Prefrontal cortex is divided into the orbit, back, medial and lateral, of which the Ministry of orbital and medial, lateral part of the back and closer to the structure and function. PF and other regions of the brain has a close relationship. PF and all have a sensory area of the fiber link between its orbital and ventral medial division of the rear projection to the parahippocampal gyrus and hippocampus before the offal of the fiber, the composition of the medial temporal lobe - the brain part of the system between the ; PF and the striatum, the amygdala, temporal lobe, occipital and parietal brain regions such as the link is also very close 〔1,2〕, therefore, PF with a variety of sensory information processing, memory, thinking and emotional brain advanced function. View from the cellular level, PF neurons with multi-sensory nature of their participation in a variety of information processing; the same time, PF neurons with columnar organization, the performance of functional heterogeneity, such as the number of PF neurons in the delayed response of the delay period of discharge significantly increased, while others on the behavior of neurons are more sensitive to other features 〔3〕. PF neurons of these structural and functional characteristics of their memory plays an important role in the neural basis of. Behavior Research also confirmed that PF is closely related with the memory function, including working memory, source memory, sequential organization, the release of proactive inhibition (PI) ability to suppress the interference of irrelevant information, meta memory, organizati