Solid dispersion technology to improve the dissolution characteristics of vinpocetine.docVIP

 PAGE \* MERGEFORMAT 11 Solid dispersion technology to improve the dissolution characteristics of vinpocetine Authors: CHEN Ying, CHEN Song, Tony Tan, Rui-Hua Wang, Li Gao [Abstract] Objective of solid dispersion technology to improve vinpocetine (VIN) of the in vitro dissolution characteristics. Methods to PEG6000, PVPK30 as the carrier, with the melting, solvent Preparation of vinpocetine solid dispersion, differential thermal analysis, X  ray powder diffraction analysis to identify the presence of drugs in the carrier in the state and carried out the stability tests and in vitro dissolution test, examining the amount of carrier, carrier added to the amount of surfactant and dissolution medium on drug dissolution characteristics. Results VIN  PEG6000 solid dispersion of drug part of the molecular state of dispersion, partly in microcrystalline dispersion; VIN  PVPK30 solid dispersion of drug to amorphous state of existence; VIN  PVPK30 drug dissolution was better than VIN  PEG6000, but the stability of the not as good as VIN  PEG6000; vector dosage, dosage of surfactant and dissolution medium on drug dissolution has a certain impact. Conclusion vinpocetine solid dispersion VIN  PEG6000  sodium dodecyl sulfate (1:6:0.8) can significantly increase the speed and extent of drug dissolution. [Keywords:] vinpocetine; solid dispersion; PEG6000; PVPK30; surface active agent; in vitro dissolution Abstract: Objective To prepare vinpocetine (VIN) solid dispersion (SD) and improve the dissolution profile of vinpocetine. Methods VIN  SD was prepared with PEG6000, PVPK30 as carriers by melting or solvent methods. Differential thermal analysis and powder X  ray diffraction were used to determine the status of drug in carriers. The effects of the carrier ratio, surfactant ratio and dissolution media on the stability and the dissolution characteristics in vitro were studied. Results Vinpocetine in VIN  PEG6000  SD existed partly as molecules and pa