Solid phase extraction gas chromatographyisotope dilution tandem mass spectrometry in the musk xylene Cosmetics_0.docVIP

 PAGE \* MERGEFORMAT 19 Solid phase extraction gas chromatographyisotope dilution tandem mass spectrometry in the musk xylene Cosmetics Study: Birch Chao Ma Ma Qiang Zhou Xin Dong Yiyang micro Zhang Xiao Haiqing Wang Baolin [Abstract] for the determination of musk xylene in cosmetics by solid phase extraction and isotope dilution gas chromatography tandem mass spectrometry analysis. Cream, water, loose powder, shampoo, lipstick and other cosmetic samples of different types of ultrasonic extraction by adding methanol, the samples extract high-speed centrifugation, concentrated supernatant to Sep Pak Silica solid phase extraction cartridges, collection dichloromethane eluent, DB 5 MS (30 m × 0.25 mm, 0.25 μm capillary column separated by NCI GC MS / MS multiple reaction monitoring technology for qualitative and quantitative analysis. xylene musk method limit of quantification was 5 μg / kg, in 5 ~ 50 μg / kg within 3 months, the average recovery of added standard was 81.1% to 86.9% day precision were less than 10%, inter-day precision were less than 12%. This method is accurate, rapid, sensitive and can be used for cosmetics, the actual inspection work. [Keywords:] solid phase extraction, isotope dilution, gas chromatography tandem mass spectrometry, cosmetics, musk xylene 1 Introduction Musk xylene (Musk xylene chemical name 1,3-dimethyl-2,4,6-trinitro-5-tert-butyl benzene, is a synthetic aromatic nitro-musk compounds, commonly used for cosmetics and soap flavor fixative agent [1]. xylene musk as a very persistent, bioaccumulative substances [2,3], has been the EU Chemicals Agency as a matter of high concern [4]. China Hygienic Standard for Cosmetics [5] and the EU Cosmetics Regulations (Council Directive 76/768/EEC [6] the provisions of musk xylene in the components for the cosmetics of restricted substances (not used for oral hygiene products, in essence, toilet water and other products were 1.0% limit, 0.4% and 0.03%. International Day of the