Solid drug polymorphs Research.docVIP

 PAGE \* MERGEFORMAT 17 Solid drug polymorphs Research [Abstract] Objective To emphasize the early drug research and development stage of solid polymorphs of the importance of the study and introduce the study of drug polymorphs several means. Method of access to relevant literature in conjunction with research experience, summarized the research on drug crystal form and discussed the identification of solid crystalline form of drug research method, crystal form of drugs on the bioavailability of a chilling effect on the factors of solid crystalline form of drugs and research of drugs Polymorphs significance. The results and conclusions should be based on the specific circumstances of drug crystal form, select the appropriate research methods to determine the appropriate target crystal. [Keywords:] solid drugs; Polymorphism; bioavailability Solid material in accordance with its internal atoms, ions or molecules can be divided into crystalline arrangement (including the pseudo-crystal type) and amorphous. Crystal formation is based on the interaction between the material particles of drug mode of action between the particles can be metal bond, covalent bond, van der Waals forces and so on, so crystals can be divided into metal crystals, covalent crystals, molecular crystals, etc. [ 1]. Most crystals of organic molecular crystals of drugs may be due to different crystallization conditions get a different crystal form, a phenomenon known as polymorphism. Polymorphism of drugs is extremely common crystal form is different from their physical properties such as density, melting point, hardness, appearance, solubility and dissolution rate, etc. There was a significant difference between [2 ~ 3]. At a certain temperature and pressure, the multi-crystalline form is stable in only one type, the minimum solubility, chemical stability is good, the other crystalline form of meta-stable type, which could eventually transform to the stable type. Generally speaking, sub-st