Sporadic Alzheimer#39;s disease BDNF gene G196A and C270T haplotype and two-body analysis of.docVIP

 PAGE \* MERGEFORMAT 23 Sporadic Alzheimer#39;s disease BDNF gene G196A and C270T haplotype and two-body analysis of Author: Qian Yun, Zhang Jun, Zhang Xiaobin, Yuan Yong-gui, Yuhui, Shi Yongmei, Bofeng, Hsieh Chun-Ming 【Abstract】 Objective: To explore the brain-derived neurotrophic factor (BDNF) gene G196A and C270T single nucleotide polymorphisms (SNPs) in sporadic Alzheimer’s disease (sAD) in the pathogenesis role. Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, 105 cases of sAD patients and 105 healthy controls BDNF gene, apolipoprotein E (ApoE) gene polymorphism analysis. Results: (1) sAD in patients with C270T, but not G196A genotypes and allele frequency difference compared with the control group was statistically significant (P = 0.034, P = 0.011). (2) BDNF G196A and C270T haplotype analysis found that four kinds of haplotypes in the sAD and control groups was statistically significant difference (P = 0.048). The control group H4 haplotype frequencies were significantly higher than sAD group, the difference was statistically significant (P = 0.024); by ApoEε4 stratified in a non-ApoEε4 carriers, this difference is still statistically significant (P = 0.023). H4-based dual-control group, the frequency was significantly higher than sAD size group, the difference was statistically significant (P = 0.029); by ApoEε4 stratified in a non-ApoEε4 carriers, this difference is still statistically significant (P = 0.040) . Conclusion: BDNF C270T locus of the SNP may be related to sAD susceptibility, H4 haplotype and its body is composed of pairs of sAD genetic protective factors for non-ApoEε4 carriers is particularly true. Keywords: Alzheimer’s disease; brain-derived neurotrophic factor; apolipoprotein E; haplotype; pairs of size Alzheimer’s disease (Alzheimer disease, AD) etiology has not yet been clear that genetic factors are important risk factors for its pathogenesis [1]. Studies