Staphylococcal enterotoxin B anti-tumor effect of research.docVIP

 PAGE \* MERGEFORMAT 23 Staphylococcal enterotoxin B anti-tumor effect of research Author: Wang Hai, Cheng Fu, Xue-Ying Hu Abstract secreted by Staphylococcus aureus enterotoxin B (SEB) is a kind of superantigen exotoxins in nature, has to stimulate T cell activity, improve the immune level, in particular the level of cell-mediated immunity. SEB has the right MHC Ⅱ selective role of class I molecules could activate peripheral blood T cells, NK cells in regulating anti-tumor effects, and to stimulate lymphocytes TFN-α and activation of TH1 cells, the role of anti-tumor effects. A large number of in vitro and animal experiments to prove, SEB treatment of cancer has a marked effect and toxic side effects of the advantages is an effective treatment of cancer of biological agents, with a wide range of medical prospects. Keywords: Staphylococcus aureus enterotoxin B Research Progress on Antitumor Effect of Staphylococcal Enterotoxin B Abstract: Staphylococcal Enterotoxin B (SEB) is a superantigen exotoxin which can stimulate T cell activation and increase the immunity, especially the cell immunity. SEB has selective and adherive effect to major histocompability complex-Ⅱ (MHC Ⅱ), it can activate peripheral blood T cells and regulate NK cell for antitumor effect. It also can stimulate TH1 activity and lymphocyte to produce TFN-α. Numerous animal and in vitro experiments have proven that SEB has the merit of high efficiency of antitumor and low toxicity, so it is an effective biological agent for tumor with bright future. Keywords:: staphylococcal enterotoxin B; neoplasms; biological injections Staphylococcal enterotoxin (staphylococcal enterotoxin, SE) from Staphylococcus aureus (hereinafter referred to as Staphylococcus aureus) secreted by a class of superantigen exotoxins in nature, the 20th century, 70 years SE was found in peripheral blood lymphocytes are activated role, initially thought it a general mitogen, as ther