Tongxinluo capsule on the apolipoprotein E knockout mice coronary atherosclerosis and its mechanism.docVIP

 PAGE \* MERGEFORMAT 19 Tongxinluo capsule on the apolipoprotein E knockout mice coronary atherosclerosis and its mechanism Of: Han Xu, Li July, Xia Weijun, Lairen Sheng, Chen Xiaohu, Guohong Min, ZHAO Hui, Liu Fuming, Zhu Bo [Abstract] Objective Tongxinluo capsule (hereinafter referred to as “TXL”) of the apolipoprotein E gene knockout mice [ApoE (-/-)] coronary plaque and myocardial histopathology and circulating endothelial cells (CEC), endothelin (ET), matrix metalloproteinase -1 (MMP-1), matrix metalloproteinase -9 (MMP-9), tissue inhibitor of matrix metalloproteinase 1 (TIMP1) and other indicators of change interventions, explore their treatment of coronary heart disease (CHD) atherosclerosis (AS) the efficacy of mechanisms. Methods 40 ApoE (-/-) mice as experimental group, the establishment of coronary AS were randomly divided into model group, simvastatin group and pass Tongxinluo high, medium and low dose group were given the appropriate drug intervention for 8 weeks; Replacement of the 8 mice with the system as a normal control group. artery plaques of mice and myocardial histopathology and the CEC, ET , MMP-1, MMP-9, TIMP1, and other indicators. Results of coronary artery disease model mice mainly located in the small intramyocardial branches, myocardial cells, myocardial interstitial, were divided into 6.33 + -1.48. simvastatin group were divided into 2.62 + -2.25; Tongxinluo low, medium and high dose groups were divided into 4.5 + -1.71,3.12 -1.81,2.38 + -2.34 +. the treatment group and model group, P lt;0.05 or P lt;0.01; Tongxinluo, the high dose group and the simvastatin group, Pgt; 0.05. the model group at week 4, blood was significantly increased in the CEC, as compared with the normal group, P lt;0.01, and TXL high dose group at 4,8,12 weeks after modeling, in comparison, P lt;0.05 or P lt;0.01, with the middle dose group in the weeks after modeling than 4,12, P lt;0.05. model group, serum ET higher than the normal group, P lt;0.05, and