Tongxinluo capsule in treating coronary heart disease systematic review of randomized controlled trials.docVIP

 PAGE \* MERGEFORMAT 32 Tongxinluo capsule in treating coronary heart disease systematic review of randomized controlled trials Author: Ho Sui-chi, WU Wei, Deng Zhuo Shen, Europe, Shun-yun, Su-Fang Liu, Zeng Tupper 【Abstract】 【Objective】 To evaluate Tongxinluo capsule and isosorbide dinitrate and other differences in the efficacy of Western medicine treatment of coronary heart disease and safety. 【Methods】 The two authors independently gather information and assess the quality into the literature, using meta analysis of quantitative data synthesis, evaluation of adverse reactions. 【Results】 (1) of the 17 studies of clinical efficacy of combined effect of an efficient amount of the test: OR combined = 2.38, its 95% CI of [1.83, 3.09] (P lt;0.01); (2) of the 12 studies ECG efficacy of combined effect of the amount of an efficient test: OR combined = 2.08,95% CI of [1.54, 2.82] (P lt;0.01); (3) there are four papers reported found Tongxinluo obvious side effects, 11 reported that gastrointestinal discomfort, headache, and so the number of cases of adverse reactions: Tongxinluo group of 17 patients, the incidence is 2.64%; control group, 63 cases, the incidence of 10.92%; (4) in the treatment group before and after the Tongxinluo blood and urine , stool, liver and kidney function, myocardial enzymes and electrolyte testing, changes were not unusual. 【Conclusion】 available evidence suggests that the clinical efficacy of Tongxinluo capsule and electrocardiogram effective than isosorbide dinitrate, and fewer adverse reactions. Subject to limitations included in the quality of literature, its efficacy to be high-quality randomized controlled trials to evaluate. Keywords: Tongxinluo capsule; coronary heart disease; angina; Meta analysis; randomized controlled trials; systematic review Abstract: 【Objective】 To evaluate the differences in curative effect on coronary heart disease between Tongxinluo capsule and western medicine like Isosorbide