三拗芎葶合剂对低氧性肺动脉高压大鼠血浆C型利钠肽和心钠肽的影响.docVIP

　　三拗芎葶合剂对低氧性肺动脉高压大鼠血浆C型利钠肽和心钠肽的影响 .L.编辑。 作者：杨仁旭，常生杰，卢小龙 【摘要】 　　目的 研究中药复方制剂三拗芎葶合剂对低氧性肺动脉高压大鼠血浆C型利钠肽（P）和心钠肽（ANP）的影响，并初步探讨其作用机制。方法 利用常压缺氧的方法复制低氧性肺动脉高压大鼠模型。雄性SD大鼠50只，随机分为5组：空白对照组、模型组、三拗芎葶合剂中剂量组、三拗芎葶合剂高剂量组及卡托普利组，每组10只。测定各组平均肺动脉压（mPAP），右室肥厚指数（RVHI），放免法测定血浆P和ANP水平。结果 三拗芎葶合剂及卡托普利均能明显降低模型大鼠的mPAP、RV／LV+S；三拗芎葶合剂各剂量组与卡托普利组疗效相当；三拗芎葶合剂及卡托普利均能部分逆转模型大鼠的肺血管重构，降低血浆P/ANP水平。但 治疗 组的上述各指标仍未完全恢复到空白对照组水平。结论 三拗芎葶合剂能有效降低肺心病模型大鼠的肺动脉高压，部分逆转肺血管结构重建，改善右心功能，可显著降低大鼠血浆C型利钠肽和心钠肽水平。 【关键词】 三拗芎葶合剂；低氧性肺动脉高压；C型利钠肽；心钠肽 ［Abstract］ Objective To study the influences of SanAoXiongTing mixture on dosage-dependence to big rats P，ANP that has been suffered from HPH and probe into its function mechanism tentatively. Methods ethod osphere to duplicate hypoxie big mouses model of high pressure of lung artery.Fifty big mice of male SD : contrast group，model group，id-dosage group，10 in every group.Respectively examining mPAP，calculating the plump index（RV/LV+S）of right heart，and examining P，ANP ethod of radiation and immunity. Results SanAoXiongTing mixture on dosage-dependence and captopril solution group can reduce mPAP，RV/LV+S of mouse obviously，SanAoXiongTing mixture on dosage-dependence group is equivalent to captopril solution group.SanAoXiongTing mixture on dosage-dependence group and captopril solution group can reverse model lung blood vessel of mouse construction again obviously，reduce P，ANP level.But every index above-mentioned in treatment the group can not totally resume to contrasting groups level normally yet. Conclusion SanAoXiongTing mixture on dosage-dependence can reduce pulmonary arterial hypertension of model mouse effectively，the lung blood vessel structure is rebuilt to reverse partly，improve the right heart function，it can reduce plasma P，ANP notably. ［Key ixture on dosage-dependence；hypoxic pulmonary hypertention;P；ANP 缺氧性肺动脉高压（HPH）是肺源性心脏病发病过程中的中心环节，HPH的产生及严重程度明显影响着肺心病的病程及预后，因此有关发病机制及治疗的研究一直是国内外研究的重点和热点。缺氧引起肺动脉高压时，心房扩张及心房压力增加可刺激心房利钠肽（ANP）的释放，同时血浆中的C型利钠肽（P）分泌增加［1］。近几年来，笔者在开展三拗芎葶