中药对多囊卵巢综合征患者糖脂代谢异常和生殖内分泌的调节作用.docVIP

　　中药对多囊卵巢综合征患者糖脂代谢异常和生殖内分泌的调节作用 【摘要】 　　［目的］探讨比较中药、二甲双胍及口服避孕药复方醋酸环丙孕酮（达因35）对多囊卵巢综合征（pcos）患者胰岛素抵抗、糖脂代谢异常和生殖内分泌的调节作用。［ 方法 ］将100例PCOS患者分成中药组40例和西药组60例，后者又随机分为二甲双胍组和达因35组各30例。观察3组患者 治疗 前后排卵恢复情况；比较体重指数、血清睾酮、空腹血糖、空腹胰岛素水平、血脂指标；稳态模型法测定的胰岛素抵抗指数。［结果］中药组、二甲双胍组和达因35组分别有36、26、25例患者完成整个治疗疗程,排卵率为33%、20%和16%。中药组明显高于二甲双胍组和达因35组，和达因35组比差异有统计学意义（Plt;0.01）；中药组治疗后空腹胰岛素、睾酮、低密度脂蛋白水平、稳态模型法测定的胰岛素抵抗指数、均下降，与治疗前比，差异有统计学意义（Plt;0.05）；与达因35组比差异有统计学意义（Plt;0.05）。［结论］中药对PCOS患者有改善胰岛素抵抗、降低低密度脂蛋白与恢复排卵和降低雄激素的作用。 【关键词】 多囊卵巢综合征 胰岛素抵抗 糖脂代谢 内分泌 　　Abstract：［Objective］ To pare the efficacy of Chinese traditional medicine,metformin and cyproterone on reducing insulin resistance,improve metabolic status of glucose and lipid and raise ovulation rate in en e.［Methods］ 100 en edicine. The rest ly divided into tetformin ent of three months.Basal body temperature （BBT）,body mass index,total testosterone,fasting serum insulin and blood sugar levels as easured and pared among all the patients before and after treatment.［Results］ No significant difference is found in the baseline characteristics among three groups before treatment.In Chinese traditional medicine group, 90％ （36／40）patients finished the treatment，and 33％ （12／36）patients ovulated.In metformin group,86％ （26／30）patients finished the treatment，and 19％ （5／26）patients ovulated.In cyproterone group,83％ （25／30）patients finished the treatment，and 16％（4/25）patients ovulated.Ovulation rate edicine group than those in metformin and cyproterone groups .There edicine group and cyproterone group（Plt;0.01）.Significant difference edicine group：after treatment the patients’ body mass index,total testosterone，serum fasting insulin,loeostasis model assessment index of insulin resistance descent significantly before treatments（Plt;0.05）.［Conclusion］ The Chinese traditional medicine can raise ovulation rate,significantly reduce insulin resistance,LDLC and total testosterone of polycysitic ovarian syndromed patients. 　　Key e；insulin resistance；glucose lipid metaboli