氟哌利多用于持续硬膜外镇痛对Q-T间期的影响.pdfVIP

• 12 • 江苏医药杂志 2005 年 1 月第 31 卷第 1 期 Jiam~su Med J , Januarv 2005 , Vol 31 , No.1 ·论著· 氟赈利多用于持续硬膜外镇痛对 Q-T 问期的影响 戴雄伟范圣登沈志忠 E摘要】 目的 研究氟赈利多临床常用剂量术后持续硬膜外自控镇痛对Q-T 间期的影响。方 法 30 例 ASA 1 - II 级女性患者在连续硬膜外麻醉下行妇科于术，术后行持续硬膜外自控镇痛，随 机分成三组，每组 10 例。三组术后均行持续硬膜外镇痛，镇痛药液总量 100 ml，内含吗啡 4 吨、 0.5%布比卡因 27ml 和生理盐水 73ml。对照组(C 组)不加其他药物;氟啄利多 1 组(且组)加氟赈 利多 5mg;氟赈利多 2 组(口。组)加氟赈利多 10mg 24、 48 h 行体表 12 导联 ECG 检 于术前与镇痛 o 查，盲法测定并计算出平均Q-Tc 时间。结果 三组患者术前Q-T 间期元显著性差异，应用镇痛泵 24 、 48 h 的Q-T 间期与术前值亦元明显差异。结论 临床剂量氟哝利多用于术后持续硬膜外自控镇 痛中对Q-T 间期无明显影响，初步提示氟哝利多用于术后持续硬膜外镇痛是安全的。 E关键词】 氟赈利多; Q-T 间期;硬膜外;镇痛 Effect of droperidol on the Q-T interval during continuous epiduraI anaIgesia DAI Xiongwei ,FAN Sen- gden , SHEN Zhizong. Department of Anesthesi叨 ， The First Hospital of Changzhou , Changzhou , 213003 , CHINA [Abstract] Objective To investigate the effect of droperidol on Q-T interval (Q-Tc ) during continuous epidural analgesia. Meth创s 30 ASA 1 - II female patients scheduled for continuous epi dural analgesia underwent abdominal gynecological operations were randomly allocated to three groups with 10 cases each. All patients in three groups were received postoperative epidural analgesia with morphine 4 mg , O. 5% bupivacaine 27 ml and normal saline 73 ml in a dose of 2 ml/h for 50 hours. Droperidol 5 mg was added to the analgesia solution in group Ds, droper词。110 mg in group ~o ， and no droperidol was used in group C. 12-1ead ECG was monitored before epidural analgesia , at 24 and 48 h during analgesia , and the Q-T intervals were calculated at the same time points in all patients. Results There were no any significant differences in Q-T interval among three groups