氯磷定持续静脉泵入治疗急性有机磷农药中毒51例分析.pdfVIP

中国黎层医药2009 年8 月第 16 卷第S 期 Chin J Prim Med Phann，Au嘟时 2饵19.Vol. I6 ， No.8 • 1385. 氯磷定持续静脉泵人治疗急性有机磷农药 中毒 51 例分析 金先银何平 J巳建斌 {摘要} 目的探讨持维静脉亵入氯磷Æ:治疗急性有机磷中毒(AOPP) 的疗效。方法 将神合重症有 机磷中毒患者分为三组:一组:静脉注射氯磷定2.0 g ，厉以 0.25 g1h 静脉泵人;二二姐:静脉注射氯磷定 2.0 g , 后以0.5 g1h 静脉兼人;主组:氯磷定每次2.0 g，每天3 次静脉滴入。观察各组疗效与并发症。结果一组与 二组比较，在加快阿托品化，减少阿托品用置，恢复胆喊酣酶洒力，缩短住院天数，随少反跳数和中间锦合征的 发生，提高治愈率方面提异无统计学意义，但两组与第二三组比较有明撞差异。结论 氯磷定前jflj ，@.踵，继以小 剂量静脉维持泵入对治疗AOPP 效果更好。 {关键词} 氯磷定:持续静脉输拉;有机磷农药;中毒 Tberapy withω.otino时 iotrave跚跚 infusim pralido袖ne chloride therapy in acute orgBooph嗣phorus pes协 dde poisoning Jin X;印n-)切， HEJí酬， WANG Jian-bi肌 Departmeru 01Respiration Huaihei People $ If，ωrpital ， Huaibei , Anhui 235创泊， Chirw. [Abstra叫 Objective To inv酬伊te the thera阳tic effect ol continuous intravenous pralidoxime chIo耐.e i抽血。.n in acute organophosphorus 伊sticíde poisoning( AOPP) . Meth创s The patient醒 with severe AOPP were ran- domly di说ded intO 3 伊Up8:(l )伊Oup 1(n = 51) received a bolus injectiOn ol pralidOxime chIOride 2. Og fOllowed by ωn出UOU8 intravenous infusion at O. 25 g1h. (2) group 2 ( n 皿51) received a bolus i吗饥tion of pralidoxime 2. Og fol幽 lowed hy cOntinuOus intravenous infusion at O.5g1h. (3) group 3 ( n 嚣 50) received intravenous 制p ol pralidoxime 2. Og for 3 time8 a day. Efficacy wωω.mp， 幽d among3 伊OUf陆 on the basis of time to reach a忧。pinization ,recovery of chOlioester刷刷vity •cumulative amount Of atropir邸. incidence ol recurrence of pesticide poisoning ,intermediate syn幽 drome ,and h08pitalization days ， e优良创创ts 区fficacy in patients 附eivi吨continuoωintravenoωtherapy w.幽 signif­ ícantly dífferent from 加thírd 萨Oup. But there w凶 00 sigr而cant dífference in e筋cacy between the first and second 伊uμ. Conclusion The patients with AOPP c栩如effectively treated by a IOadi吨dωe fOllowed with continOus in- traveoous pralidoxime chloride infusion. [Key words) 阶百lidoxime chIOride; COntinuOωinfusion 阳rapy; 问anO