Clock genes, chronotypes and diseases.docVIP

HVM BIOFLUX Human Veterinary Medicine International Journal of the Bioflux Society Clock genes, chronotypes and diseases 1 Bogdan I. Voinescu 1 “Iuliu Ha?ieganu” University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania, EU; Corresponding author: B. I. Voinescu, vbi1@clicknet.ro Abstract. Many common diseases in humans (such as cancer, heart disease, diabetes mellitus or psychiatric disorders, such as depression) seem to be linked to disruptions of circadian cycles and to clock genes variation. It is unlikely that such diseases to be caused by a genetic variation within a single gene. They must be influenced by complex interactions among multiple genes, as well as environmental and lifestyle factors. Therefore, it is important to understand how the resulting perturbations in our circadian biology could affect our physiological processes and susceptibility to disease. Associations between the polymorphisms of the main components of the circadian molecular clock, circadian type (also known as diurnal preference or chronotype) and diseases are presented. Key Words: circadian rythms, clock genes, SNPs, chronotype. Rezumat. La oameni, multe dintre boli (precum cancerul, boala cardiac?, diabetul zaharat, tulbur?ri psihiatrice, cum ar fi depresia) par s? fie ?nso?ite de modific?ri ale ciclurilor circadiene ?i varia?ii ale genelor ceasornic (genele clock). Este pu?in probabil ca astfel de boli s? fie cauzate de o varia?ie a unei singure gene. Trebuie c? sunt influen?ate de interac?iuni complexe dintre mai multe gene, al?turi de factori de mediu ?i stilul de via??. De aceea, este important s? ?n?elegem cum modific?rile din biologia circadian? ar putea afecta procesele fiziologice ?i susceptibilitatea la boal?. Asocia?ii ?ntre polimorfisme ale principalelor componente moleculare ale ceasului ci