CLINICALLY SIGNIFICANT PHARMACOKINETIC INTERACTIONS OF ANTIEPILEPTIC DRUGS.docVIP

Review article CLINICALLY SIGNIFICANT PHARMACOKINETIC INTERACTIONS OF ANTIEPILEPTIC DRUGS Radmila Velickovic- Radovanovic, Aleksandra Catic-Djordjevic and Milena Dimic Antiepileptic drugs show clinically significant interactions among themselves as well as with other medications, because of a specific pharmacokinetic profile and relatively small therapeutic spectrum. The most significant clinical interactions of AE occur during their metabolism and distribution. In the combined antiepileptic therapy, it is very important to know the order of application of AE because of their influence on liver enzymes and the affinity to attach to plasma proteins. The AE with shorter half-time elimination have a greater potential for interaction which is why therapy monitoring is recommended. Populational pharmacokinetic analysis can provide significant information concerning interactions of AE with other medications. Vulnerable, pediatric population is under a special risk of developing interactions alongside patients with liver and kidney function damage. Acta Medica Medianae 2007;46(4):55-60. Key words: pharmacokinetic interactions, antiepileptic drugs, interaction potential, clinical significance Faculty of Medicine 1 interactions of AE are mainly quantitive and easily predictible. They occur in locations of Institute for Mental Health of the Clinical Center in Nis 2 pharmacokinetic processes and are always Contact: Aleksandra Catic- Djordjevic Pharamcokinetics, Department of Pharmacy Faculty of Medicine, Unviersity of Nis 85 Dr Zoran Djindjic 18000 Nis, Serbia Tel.: +381-18-570-029 followed by changes in the plasma concentration of medications. Compared to pharmacodynamic interactions, they are more studied and more easily identified and quantified (2,3). E-mail:aleksandra@medfak.ni.ac.yu Pharmacokinetic processes significant for interaction occure