年产一千吨阿司匹林生产车间工艺设计.doc

年产1000吨阿司匹林生产车间设计 阿司匹林又名乙酰水杨酸，自1897年被首次合成之后，便被广泛使用。它是历史上使用时间最长，用量最大的化学药物之一。除去传统的温和的解热镇痛等药理作用外，随着科技的发展，并发现其还有防治癌症，治疗结膜炎、老年痴呆症、抗生素所致听力障碍、脚癣、白内障、偏头痛、艾滋病以及降血糖的作用。这个上世纪最神奇的药物，已经焕发出了青春，科学工作者们正在探索它各种新的效用，将为这老药撰写新传。鉴于其有广阔的发展空间和良好的市场前景，故大规模生产很有必要。 本文用醋酐和水杨酸为原料，以乙酸钠为催化剂生产阿司匹林。工艺过程简单，产品纯度高，是阿司匹林生产的一条高产、优质、低成本的有效途径。在此基础上设计了一个年产1000吨阿司匹林的GMP生产车间，并且根据工艺特点确定反应周期，通过物料衡算得到每一种所需原料的质量后根据衡算结果进行设计，通过热量衡算最后给出了生产工艺平面布置图工艺管道流程图。 Abstract Aspirin, also named acetylsalicylic acid, was first synthesized in 1897 to be extensively used as one of the longest-history and the largest-production chemical medicines. In spite of the traditional mild pharmacological effects of antipyrexia and abirritation, with the development of science and technology, it has also found the effects of preventing and treating cancer, conjunctivitis, alzheimer, hearing impairment caused by antibiotics, athletes foot, cataracts, migraine, AIDS and lowering blood sugar. The most amazing drug in the last century has shown its promise at wide development space and good market prospect for its new effects was exploring nowadays by scientific workers. Therefore it is necessary to large-scale production. This article gives a way of producing aspirin with acetic acid sodium as catalyst production by using acetic anhydride and salicylic acid as raw material. It is an aspirin production with high yield, good quality and low cost effective way of simple process, high purity. An annual output of 1,000 tons of aspirin GMP production workshop based on it is designed. And research has been done, such as to determine reaction cycle according to the technological characteristics, to get each needed heat raw material quality through the material balance, to obtain the required heat quantity through the heat balance in transformation, then to design axe body and pipeline according to the calculation, finally to present the production process layout and process piping flow chart. Keywords aspirin；process；production workshop；w