Association of Body Mass Index with Cause Specific Deaths in Chinese Elderly Hypertensive Patients Minhang Community Study.docVIP

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Association of Body Mass Index with Cause Specific Deaths in Chinese Elderly Hypertensive Patients Minhang Community Study.doc

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Association of Body Mass Index with Cause Specific Deaths in Chinese Elderly Hypertensive Patients Minhang Community Study

AssociationofBodyMassIndexwithCauseSpecific DeathsinChineseElderlyHypertensivePatients: MinhangCommunityStudy YanWang1,2.,YajuanWang3.,YueshengQain1,2,JinZhang1,2,XiaofengTang1,2,JunleiSun3*, DingliangZhu1,2 * 1State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 2Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine, Shanghai, China, 3Xinzhuang CommunityHealthServiceCenter,Shanghai,China Abstract Background:Moststudieshavesuggestedthatelevatedbodymassindex(BMI)wasassociatedwiththeriskofdeathfrom allcauseandfromspecificcauses.However,therewaslittleevidenceillustratingtheeffectofBMIonthemortalityinelderly hypertensivepatientsinChinesepopulation. Methods:Theinformationof10,957hypertensivepatientsatbaselinenotlessthan60yearswerefromXinzhuang,atown inMinhangdistrictofShanghai,wasextractedfromtheElectronicHealthRecord(EHR)system.Allstudyparticipantswere dividedintoeightcategoriesofbaselineBMI(withcut-pointsat18,20,22,24,26,28and30kg/m2).Relativehazardratioof deathfromallcause,cardiovascularandnon-cardiovascularcausebybaselineBMIgroupswerecalculated,standardizedfor sex, age, smoking, drinking, physical activity, systolic blood pressure, history of cardiovascular disorders, serum lipid disturbance,diabetesmellitusandantihypertensivedrugtreatment. Results: During follow up (median: 3.7 years), 561 deaths occurred. Underweight (BMI,18kg/m2) was associated with significantlyincreasedmortalityfromallcausemortality(OR:2.00;95%CI:1.43–2.79)andnoncardiovascularmortality(OR: 2.76; 95% CI: 1.87–4.07), but not with cardiovascular mortality. For the cause specific analysis, the underweight was associatedsignificantlywithneoplasms(OR:2.15;95%CI:1.16–4.00)andrespiratorydisorders(OR:3.41;95%CI:1.64–7.06). Theresultsfortotalmortalityandspecificcausemortalitywerenotinfluencedbysex,ageandsmokingstatus. Conclusion: O