Association Rule Mining and Network Analysis in Oriental Medicine.docVIP

AssociationRuleMiningandNetworkAnalysisin OrientalMedicine DongHoonYang1,JiHoonKang2,YoungBaePark1,YoungJaePark1,HwanSupOh3,4 ,Seoung BumKim2* 1Department of Biofunctional Medicine and Diagnostics, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul, Republic of Korea, 2School of Industrial Management Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, Republic of Korea, 3Department of Human Informatics of Oriental Medicine, InterdisciplinaryPrograms,KyungHeeUniversity,Giheung-gu,Yongin,Gyeonggi-do,RepublicofKorea,4DepartmentofMechanicalEngineering,KyungHeeUniversity, Giheung-gu,Yongin,Gyeonggi-do,RepublicofKorea Abstract Extractingusefulandmeaningfulpatternsfromlargevolumesoftextdataisofgrowingimportance.Inthepresentstudy weanalyzevastamountsofprescriptiondata,generatedfromthebookoforientalmedicinetoidentifytherelationships betweenthesymptomsandtheassociatedmedicinesusedtotreatthesesymptoms.Theorientalmedicinebookusedin thisstudy(calledBangyakhappyeon)containsalargenumberofprescriptionstotreatabout54categorizedsymptomsand liststhecorrespondingherbalmaterials.Weusedanassociationrulealgorithmcombinedwithnetworkanalysisandfound usefulandinformativerelationshipsbetweenthesymptomsandmedicines. Citation:YangDH,KangJH,ParkYB,ParkYJ,OhHS,etal.(2013)AssociationRuleMiningandNetworkAnalysisinOrientalMedicine.PLoSONE8(3):e59241. doi:10.1371/journal.pone.0059241 Editor:VladimirBrusic,Dana-FarberCancerInstitute,UnitedStatesofAmerica ReceivedJuly23,2012;AcceptedFebruary14,2013;PublishedMarch15,2013 Copyright: ? 2013 Yang etal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was support in part by Brain Korea 21. The funders had no role in study design, data collection and analysis, decision to publish, or preparationofthemanuscript.Noadditionalexternalfundingreceivedforthisstud