Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls.docVIP

AssociationStudyofCommonGeneticVariantsandHIV- 1Acquisitionin6,300InfectedCasesand7,200Controls PaulJ.McLaren1,2,3.,Ce′dricCoulonges4,5.,StephanRipke3,6,LeonardvandenBerg7,SusanBuchbinder8, MaryCarrington9,10,AndreaCossarizza11,JudithDalmau12,StevenG.Deeks13,OlivierDelaneau14,AndreaDe Luca15,16,JamesJ.Goedert17,DavidHaas18,JoshuaT.Herbeck19,SekarKathiresan3,20,GregoryD.Kirk21, OlivierLambotte22,23,24,MaLuo25,26,SimonMallal27,Danie¨llevanManen28¤,JavierMartinez-Picado12,29 LaurenceMeyer5,30,Jose′ M.Miro31,JamesI.Mullins19,NielsObel32,StephenJ.O’Brien33, , FlorenciaPereyra10,34,FrancisA.Plummer25,26,GuidoPoli35,YingQi9,PierreRucart4,5,ManjS.Sandhu36,37 PatrickR.Shea38,HannekeSchuitemaker28¤,IoannisTheodorou5,39,FredrikVannberg40,JanVeldink7, BruceD.Walker10,41,AmyWeintrob42,CherylA.Winkler43,StevenWolinsky44,AmalioTelenti2, , DavidB.Goldstein38,PaulI.W.deBakker3,45,46,47,Jean-Franc?oisZagury4,5,JacquesFellay1,2 * 1SchoolofLifeSciences,E′colePolytechniqueFe′de′raledeLausanne,Lausanne,Switzerland,2InstituteofMicrobiology,UniversityHospitalCenterandUniversityofLausanne, Lausanne,Switzerland,3PrograminMedicalandPopulationGenetics,BroadInstituteofMITandHarvard,Cambridge,Massachusetts,UnitedStatesofAmerica,4Laboratoire Ge′nomique,Bioinformatique,etApplications,EA4627,ChairedeBioinformatique,ConservatoireNationaldesArtsetMe′tiers,Paris,France,5ANRSGenomicGroup(French AgencyforResearchonAIDSandHepatitis),Paris,France,6CenterforHumanGeneticResearch,MassachusettsGeneralHospital,HarvardMedicalSchool,Boston,Massachusetts, UnitedStatesofAmerica,7DepartmentofNeurology,RudolfMagnusInstituteofNeuroscience,UniversityMedicalCenterUtrecht,Utrecht,TheNetherlands,8BridgeHIV,San FranciscoDepartmentofPublicHealth,SanFrancisco,California,UnitedStatesofAmerica,9CancerandInflammationProgram,LaboratoryofExperimentalImmunology,SAIC Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, 10Ragon Institute of MGH, MIT and Harvard, Bosto