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Automatic Diagnosis of Pathological Myopia from Heterogeneous Biomedical Data.doc

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Automatic Diagnosis of Pathological Myopia from Heterogeneous Biomedical Data

AutomaticDiagnosisofPathologicalMyopiafrom HeterogeneousBiomedicalData ZhuoZhang1,2*,YanwuXu1,JiangLiu1,DamonWingKeeWong1,CheeKeongKwoh2,Seang-MeiSaw3, TienYinWong4 1Institute for Infocomm Research, Agency for Science, Technology and Research, Singapore, Singapore, 2School of Computer Engineering, Nanyang Technological University,Singapore,Singapore,3SawSweeHockSchoolofPublicHealth,NationalUniversityofSingapore,Singapore,Singapore, 4DepartmentofOphthalmology, SingaporeEyeResearchInstitute,Singapore,Singapore Abstract Pathological myopia is one of theleading causes of blindness worldwide. The conditionis particularly prevalent in Asia. Unlikemyopia,pathologicalmyopiaisaccompaniedbydegenerativechangesintheretina,whichifleftuntreatedcanlead to irrecoverable vision loss. The accurate diagnosis of pathological myopia will enable timely intervention and facilitate betterdiseasemanagementtoslowdowntheprogressionofthedisease.Currentmethodsofassessmenttypicallyconsider only one type of data, such as that from retinal imaging. However, different kinds of data, including that of genetic, demographic and clinical information, may contain different and independent information, which can provide different perspectivesonthevisuallyobservable,geneticorenvironmentalmechanismsforthedisease.Thecombinationofthese potentially complementary pieces of information can enhance the understanding of the disease, providing a holistic appreciation of the multiple risks factors as well as improving the detection outcomes. In this study, we propose a computer-aided diagnosis framework for Pathological Myopia diagnosis through Biomedical and Image Informatics(PM- BMII).Throughtheuseofmultiplekernellearning(MKL)methods,PM-BMIIintelligentlyfusesheterogeneousbiomedical informationtoimprovetheaccuracyofdiseasediagnosis.Datafrom2,258subjectsofapopulation-basedstudy,inwhich demographic and clinical information, retinal fundus imaging data and genotyping data were collected, are used to evalua