BDNF Val66Met Variant and Smoking in a Chinese Population.docVIP

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BDNF Val66Met Variant and Smoking in a Chinese Population.doc

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BDNF Val66Met Variant and Smoking in a Chinese Population

BDNFVal66MetVariantandSmokinginaChinese Population XiangYangZhang1,2*.,DaChunChen2.,MeiHongXiu2.,XingguangLuo3,LingjunZuo3,ColinN.Haile1, ThereseA.Kosten1,ThomasR.Kosten1,2* 1Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America, 2Psychiatric Research Center, BeijingHui-Long-Guanhospital,PekingUniversity,Beijing,China,3DepartmentofPsychiatry,YaleUniversity,NewHaven,Connecticut,UnitedStatesofAmerica Abstract Several recent studies have supported the hypothesis that brain-derived neurotrophic factor (BDNF), a member of the neurotrophicfactorfamily,mightbeassociatedwithnicotineaddiction.Associationstudieshavealsosuggestedthatthe BDNF genemight play arole in the susceptibility to nicotinedependence but results appear contradictory. The present work was therefore undertaken to examine the association of smoking with the BDNF Val66Met gene polymorphism in Chinesepopulation.TheBDNFVal66Metgenepolymorphismwasexaminedin628healthymalevolunteersincluding322 smokersand306non-smokers.Also,theBDNFserumlevelsweremeasuredin136smokersand97nonsmokers.Ourresults showednosignificantassociationbetweentheBDNFVal66Metpolymorphismorserumlevelsamongsmokersandnon- smokers.SmokerswiththeMetallelehoweverstartedsmokingsignificantlyearlierthanthosewiththeVal/Valgenotype (meanageatsmokinginitiationof17.4,17.9and21.2yearsforMet/Met,Met/Val,andVal/Val,respectively;bothp,0.05).No othersignificantdifferencesbetweenothervariablessuchasnumberofcigarettesperday,smokingseverityasmeasured bytheFagerstromTestforNicotineDependence(FTND)scoreandcarbonmonoxide(CO)levels(allp.0.05).Inaddition, therewasnomaineffectofgenotypeonserumBDNFlevels.OurfindingssuggestthattheBDNFVal66Metpolymorphism maynotbeinvolvedinsusceptibilitytosmokingamongtheChinesemalepopulation,butmayinfluencetheageatwhich smokingisinitiated.However,thefindingsmustbeinterpretedwithcautionbecauseoftherelativelysmallsamplesizefor anassociationstudy.Resultsshouldbeconfirme