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Cerebrospinal Fluid Interleukin-6 in Central Nervous System Inflammatory Diseases
CerebrospinalFluidInterleukin-6inCentralNervous
SystemInflammatoryDiseases
AlexandreWullschleger1,ViktoriaKapina1,NicolasMolnarfi1,2,DelphineS.Courvoisier3,4
,
Jo¨rgD.Seebach5,Marie-LaureSantiago-Raber2,DenisF.Hochstrasser6,PatriceH.Lalive1,2,6*
1DepartmentofClinicalNeurosciences,DivisionofNeurology,UniversityHospitalofGeneva,Geneva,Switzerland,2DepartmentofPathologyandImmunology,Faculty
ofMedicine,UniversityofGeneva,Geneva,Switzerland,3DivisionofClinicalEpidemiology,UniversityHospitalsofGeneva,Geneva,Switzerland,4SchoolofPublicHealth,
Harvard University, Boston, Massachusetts, United States of America, 5Department of Internal Medicine, Division of Clinical Immunology and Allergology, University
Hospital and Medical Faculty, Geneva, Switzerland, 6Department of Genetics and Laboratory Medicine, Laboratory Medicine Service, University Hospital of Geneva,
Geneva,Switzerland
Abstract
Background: Interleukin (IL)-6 is recognised as an important cytokine involved in inflammatory diseases of the central
nervoussystem(CNS).
Objective: To perform alarge retrospective study designed to test cerebrospinal fluid (CSF)IL-6 levelsin thecontext of
neurological diseases, and evaluate its usefulness as a biomarker to help discriminate multiple sclerosis (MS) from other
inflammatoryneurologicaldiseases(OIND).
PatientsandMethods:Weanalyzed374CSFsamplesforIL-6usingaquantitativeenzyme-linkedimmunosorbentassay.
GroupstestedwerecomposedofdemyelinatingdiseasesoftheCNS(DD,n=117),includingrelapsing-remittingMS(RRMS,
n=65),primaryprogressiveMS(PPMS,n=11),clinicallyisolatedsyndrome(CIS,n=11),opticneuritis(ON,n=30);idiopathic
transverse myelitis (ITM, n=10); other inflammatory neurological diseases (OIND, n=35); and non-inflammatory
neurological diseases (NIND, n=212). Differences between groups were analysed using Kruskal2Wallis test and
Mann2WhitneyU-test.
Results:CSFIL-6levelsexceededthepositivitycut-offof10pg/mlin18(51.4%)ofthe35OINDsamples,butinonlythree
(3.9%)ofthe76MSsamplescollecte
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