Competence-Independent Activity of Pneumococcal Enda Mediates Degradation of Extracellular DNA and Nets and Is Important for Virulence.docVIP

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Competence-Independent Activity of Pneumococcal Enda Mediates Degradation of Extracellular DNA and Nets and Is Important for Virulence.doc

Competence-Independent Activity of Pneumococcal Enda Mediates Degradation of Extracellular DNA and Nets and Is Important for Virulence

Competence-IndependentActivityofPneumococcal EndaMediatesDegradationofExtracellularDNAand NetsandIsImportantforVirulence LuchangZhu1,ZhizhouKuang1,BrendaA.Wilson2,GeeW.Lau1* 1DepartmentofPathobiology,UniversityofIllinoisatUrbana-Champaign,Urbana,Illinois,UnitedStatesofAmerica,2DepartmentofMicrobiology,UniversityofIllinoisat Urbana-Champaign,Urbana,Illinois,UnitedStatesofAmerica Abstract MembranesurfacelocalizedendonucleaseEndAofthepulmonarypathogenStreptococcuspneumoniae(pneumococcus)is required for both genetic transformation and virulence. Pneumococcus expresses EndA during growth. However

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Competence-Independent Activity of Pneumococcal Enda Mediates Degradation of Extracellular DNA and Nets and Is Important for Virulence.docVIP