Compensatory Base Changes in ITS2 Secondary Structures Correlate with the Biological Species Concept Despite Intragenomic Variability in ITS2 Sequences – A Proof of Concept.docVIP

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Compensatory Base Changes in ITS2 Secondary Structures Correlate with the Biological Species Concept Despite Intragenomic Variability in ITS2 Sequences – A Proof of Concept.doc

Compensatory Base Changes in ITS2 Secondary Structures Correlate with the Biological Species Concept Despite Intragenomic Variability in ITS2 Sequences – A Proof of Concept

CompensatoryBaseChangesinITS2Secondary StructuresCorrelatewiththeBiologicalSpeciesConcept DespiteIntragenomicVariabilityinITS2Sequences–A ProofofConcept MatthiasWolf1*,ShilinChen2,JingyuanSong2,MarkusAnkenbrand1,TobiasMu¨ller1 1Department of Bioinformatics, Biocenter, University of Wu¨rzburg, Wu¨rzburg, Germany, 2Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences,PekingUnionMedicalCollege,Beijing,China Abstract Compensatorybasechanges(CBCs)ininternaltranscribedspacer2(ITS2)rDNAsecondarystructurescorrelatewithErnst Mayr’sbiologicalspeciesconcept.Thishypothesisalsore

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Compensatory Base Changes in ITS2 Secondary Structures Correlate with the Biological Species Concept Despite Intragenomic Variability in ITS2 Sequences – A Proof of Concept.docVIP