原创力文档Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae 英文论文文献.docVIP
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Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae 英文论文文献
Greethametal.BMCBiochemistry2010,11:3
/1471-2091/11/3
RESEARCH ARTICLE
OpenAccess
Thioredoxinsfunctionasdeglutathionylase
enzymesintheyeastSaccharomycescerevisiae
DarrenGreetham1,JillVickerstaff1,DanielShenton1,GabrielGPerrone1,2,IanWDawes1,2,ChrisMGrant1*
Abstract
Background:Protein-SHgroupsareamongstthemosteasilyoxidizedresiduesinproteins,butirreversible
oxidationcanbepreventedbyproteinglutathionylation,inwhichprotein-SHgroupsformmixeddisulphideswith
glutathione.Glutaredoxinsandthioredoxinsarekeyoxidoreductaseswhichhavebeenimplicatedinregulating
glutathionylation/deglutathionylationindive
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