tmle An R Package for Targeted Maximum Likelihood Estimation 英文论文文献.docVIP

JournalofStatisticalSoftware November2012,Volume51,Issue13. / tmle: An R Package for Targeted Maximum Likelihood Estimation Susan Gruber HarvardSchoolofPublicHealth Mark J. van der Laan UniversityofCalifornia,Berkeley Abstract Targetedmaximumlikelihoodestimation(TMLE)isageneralapproachforconstruct- ing an e?cient double-robust semi-parametric substitution estimator of a causal e?ect parameterorstatisticalassociationmeasure. tmleisarecentlydevelopedRpackagethat implements TMLE of the e?ect of a binary treatment at a single point in time on an outcome of interest, controlling for user suppli