Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation 英文论文文献.docVIP
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Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation 英文论文文献
Worthingtonetal.BMCCancer2010,10:490
/1471-2407/10/490
RESEARCH ARTICLE
OpenAccess
TranscriptionalprofilingofErbBsignallingin
mammaryluminalepithelialcells-interplayof
ErbBandIGF1signallingthroughIGFBP3
regulation
JennyWorthington1?,MarianaBertani2?,Hong-LinChan3,BertranGerrits2,JohnFTimms1*
Abstract
Background:MembersoftheErbBfamilyofgrowthfactorreceptorsareintricatelylinkedwithepithelialcell
biology,developmentandtumourigenesis;however,themechanismsinvolvedintheirdownstreamsignallingare
poorlyunderstood.Indeed,itisunclearhowsignalspecificityisachievedandtherelativecontributioneach
recepto
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