Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate 英文论文文献.docVIP

Wang et al. BMC Genomics 2010, 11:360 /1471-2164/11/360 RESEARCH ARTICLE Open Access Transcriptomic responses in mouse brain exposed Research article to chronic excess of the neurotransmitter glutamate Xinkun Wang*1,2, Xiaodong Bao1,2, Ranu Pal1,2, Abdulbaki Agbas2,3 and Elias K Michaelis1,2 Abstract Background: Increases during aging in extracellular levels of glutamate (Glu), the major excitatory neurotransmitter in the brain, may be linked to chronic neurodegenerative diseases. Little is known about the molecular responses of neurons to chronic, moderate increases in Glu levels. Geno