Trichostatin A enhances acetylation as well as protein stability of ERα through induction of p300 protein 英文论文文献.docVIP

Kim et al. Breast Cancer Research 2010, 12:R22 /content/12/2/R22 RESEARCH ARTICLE Open Access Trichostatin A enhances acetylation as well as Research article protein stability of ERα through induction of p300 protein Sung-Hye Kim1,2,3, Hyun-Jin Kang1,2,3, Hyelin Na1,2,3 and Mi-Ock Lee*1,2,3 Abstract Introduction: Trichostatin A (TSA) is a well-characterized histone deacetylase (HDAC) inhibitor. TSA modifies the balance between HDAC and histone acetyltransferase activities that is important in chromatin remodeling and gene expression. Although several previous studies have demonstrated