Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes 英文论文文献.docVIP
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Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes 英文论文文献
Buschetal.BMCGenomics2010,11:65
/1471-2164/11/65
RESEARCH ARTICLE
OpenAccess
Tungstencarbidecobaltnanoparticlesexert
hypoxia-likeeffectsonthegeneexpressionlevel
inhumankeratinocytes
WibkeBusch1*,DanaKühnel1,KristinSchirmer2,StefanScholz1
Abstract
Background:Tungstencarbide(WC)andtungstencarbidecobalt(WC-Co)nanoparticlesareofoccupationalhealth
relevancebecauseoftheincreasingusageinhardmetalindustries.Earlierstudiesshowedanenhancedtoxic
potentialforWC-CocomparedtoWCorcobaltionsalone.Therefore,weinvestigatedtheimpactoftheseparticles,
comparedtocobaltionsappliedasCoCl2,ontheglobalgeneexpression
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