Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design 英文论文文献.docVIP

Boghigian et al. BMC Systems Biology 2010, 4:49 /1752-0509/4/49 RESEARCH ARTICLE Open Access Utilizing elementary mode analysis, pathway Research article thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design Brett A Boghigian, Hai Shi, Kyongbum Lee and Blaine A Pfeifer* Abstract Background: Microbial hosts offer a number of unique advantages when used as production systems for both native and heterologous small-molecules. These advantages include high selectivity and benign environmental impact; however, a principal drawback is