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Variability of gene expression profiles in human blood and lymphoblastoid cell lines 英文论文文献
Minetal.BMCGenomics2010,11:96
/1471-2164/11/96
RESEARCH ARTICLE
OpenAccess
Variabilityofgeneexpressionprofilesinhuman
bloodandlymphoblastoidcelllines
JosineLMin1*,AmyBarrett2,TimWatts3,FredrikHPettersson1,HelenELockstone4,CeciliaMLindgren1,
JenniferMTaylor4,MaxineAllen2,KrinaTZondervan1,MarkIMcCarthy2*
Abstract
Background:Readilyaccessiblesamplessuchasperipheralbloodorcelllinesareincreasinglybeingusedinlarge
cohortstocharacterisegeneexpressiondifferencesbetweenapatientgroupandhealthycontrols.However,cell
andRNAisolationproceduresandthevarietyofcelltypesthatmakeupwholebloodcanaffectgeneexpre
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