原创力文档Variance heterogeneity analysis for detection of potentially interacting genetic loci method and its limitations 英文论文文献.docVIP
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Variance heterogeneity analysis for detection of potentially interacting genetic loci method and its limitations 英文论文文献
Struchalinetal.BMCGenetics2010,11:92
/1471-2156/11/92
METHODOLOGY ARTICLE
OpenAccess
Varianceheterogeneityanalysisfordetectionof
potentiallyinteractinggeneticloci:methodand
itslimitations
MaksimVStruchalin1,AbbasDehghan1,JacquelineCMWitteman1,CorneliavanDuijn1,YuriiSAulchenko1,2*
Abstract
Background:Presenceofinteractionbetweenagenotypeandcertainfactorindeterminationofatrait’svalue,itis
expectedthatthetrait’svarianceisincreasedinthegroupofsubjectshavingthisgenotype.Thus,testof
heterogeneityofvariancescanbeusedasatesttoscreenforpotentiallyinteractingsingle-nucleotide
polymorphisms(SNPs).Inth
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