9支气管肺泡灌洗液中的炎症因子在呼吸机相关性肺炎患者中的动态变化_孙雪东.pdf

2010 20 15 ·2189 · ·　 · 1 1 1 1 2 孙雪东 , 董金芳 , 陆　地, 茅尧生 , 郑　霞 (1. ICU, 312000;2. ICU, 312000) :　(VAP)(BALF), 、。 　, 2005 3 -2009 3 M ICU、SICU、NICU 80 , , (BAL), BALF, , 4 、BALF -8(IL-8)、(PCT)、C (CRP)。　 BALF IL-8、CRP、PCT , VAP , ;BALF IL-8 ;CRP BALF , ;BALF PCT , (P0.01);PCT VAP BALF IL-8、CRP , IL-8、CRP PCT 。　VAP BALF , PCT、IL-8 BALF , , BALF PCT 。 :;; + :R181.3 2　　:A　　:1005-4529(2010)15-2189-03 Dynamic Changes in Inflammatory Cytokines of Bronchoalveolar Lavage Fluid in Patients with Ventilator-associated Pneumonia ＊ SUN Xue-dong , DON Jin-fang, LU Di, MAO Yao-sheng, ZHEN Xia (＊S haox ing P eop le ′s H osp i ta l, S haox ing, Z hej iang 312000, China ) Abstract:OB ECTIVE To investigate the dynamic changes in inflammatory cytokines of bronchoalveolar lavage fluid (BALF)and serum in patients with ventilator-associated pneumonia (VAP), and the value in evaluation of the prognosis.METHODS Eighty artificial airway patients with mechanical ventilation were prospectively studied from Mar 2005 to Mar 2009 in MICU, SICU and NICU of our hospital.All the patients were done with bronchoalveolar lavage (BAL)and blood collection at the time of the admitting to ICU ward, diagnosing as VAP, 3 days after effective therapy.All the indexes of interleukin-8 (IL-8), procalcitonin (PCT), and C-reactive protein (CRP)in BALF and serum were detected at the four phases.RESULTS The dynamic changes in inflammatory cytokines in BALF were the same with that in serum.But IL-8 in BALF had compartmentalization phenomenon. The levels of CRP in serum were higher in BALF at the all phases, but there was no significant diff