α-促黑素对全肾缺血再灌注模型大鼠的作用.pdfVIP

中国组织工程研究 第 19 卷 第27 期 2015 –06 –30 出版 Chinese Journal of Tissue Engineering Research June 30, 2015 Vol.19, No.27 www.CRTER.org Effect of alpha-melanocyte in rat models of renal ischemia-reperfusion injury Jiang Yan, Zhang Zhong-yi, Xu Yan, Liu Xue-mei Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China Abstract BACKGROUND: Kidney ischemia-reperfusion injury often combines with acute kidney and lung injury. The Jiang Yan, Studying for expression of cutin cell growth factor receptor (KGFR) and alpha sodium channel protein (α-ENaC) in kidney master’s degree, Department of Nephrology, Affiliated and lung after ischemia-reperfusion injury and the protective effect of α-melanocyte require further observation Hospital of Qingdao and research. University, Qingdao 266003, OBJECTIVE: To explore the therapeutic effect of α-melanocyte on the expressions of KGFR and α-ENaC in rat Shandong Province, China models of ischemia-reperfusion injury. METHODS: A total of 30 healthy male Sprague-Dawley rats were randomly divided into control group, Corresponding author: Xu ischemia-reperfusion group and α-MSH group. Models of renal ischemia-reperfusion injury were established by Yan, M.D., Chief physician, 30-minute ligation of renal artery in the ischemia-reperfusion and α-melanocyte groups. Rats in the control Doct