Cytoprotective properties of rifampicin are related.pdfVIP

J Hepatobiliary Pancreat Sci (2011) 18:740–750 DOI 10.1007/s00534-011-0396-3 ORIGINAL ARTICLE Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids • • • • ´ ´ ´ ´ Raul Gonzalez Adolfo Cruz Gustavo Ferrın Pedro Lopez-Cillero • • • • ˜ ´ ´ ´ Javier Briceno Miguel A. Gomez Sebastian Rufian Javier Padillo • • ´ Manuel De la Mata Jose J. G. Marin Jordi Muntane Published online: 28 April 2011 Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2011 Abstract Methods Rifampicin was administered to glycochenode- Background/Purpose Rifampicin has been used for the oxycholic acid (GCDCA)-treated human hepatocytes and treatment of patients with jaundice and pruritus. This study bile duct-obstructed rats. Different parameters related to evaluated the effect of rifampicin on the expression of cell death, and the expression of phase I and II drug different detoxification systems and bile acid transporters metabolizing enzymes (DME) and bile acid transporters during in-vivo and in-vitro experimental models of were determined. cholestasis.