Analytical Expressions for Steady-State Concentrations of Substrate and Product in an Amperometric Biosensor with the Substrate Inhibition—The Adomian Decomposition Method英文文献资料.docVIP

American Journal of Analytical Chemistry, 2012, 3, 495-502 /10.4236/ajac.2012.38066 Published Online August 2012 (http://www.SciRP.org/journal/ajac) Analytical Expressions for Steady-State Concentrations of Substrate and Product in an Amperometric Biosensor with the Substrate Inhibition—The Adomian Decomposition Method Anandan Anitha , Shunmugham Loghambal , Lakshmanan Rajendran 1 2 1* 1 Department of Mathematics, The Madura College, Madurai, India 2 Department of Mathematics, V V College of Engineering, Tisaiyanvilai, India * Email: raj_sms@ Received June 12, 2012; revised July 18, 2012; accepted July 28, 2012 ABSTRACT A mathematical model of an amperometric biosensor with the substrate inhibition for steady-state condition is discussed. The model is based on the system of non-stationary diffusion equation containing a non-linear term related to non-Micha- elis-Menten kinetics of the enzymatic reaction. This paper presents the analytical expression of concentrations and current for all values of parameters ?s 2 ,? 2 p ,α and β . Here the Adomian decomposition method (ADM) is used to find the ana- lytical expressions for substrate, product concentration and current. A comparison of the analytical approximation and nu- merical simulation is also presented. A good agreement between theoretical predictions and numerical results is observed. Keywords: Mathematical Modeling; Non-Linear Equation; Adomian Decomposition Method; Amperometric Biosensor; Reaction-Diffusion System; Substrate Inhibition 1. Introduction [2]. The dimensionless model of the biosensor with sub- strate and product inhibition has been constructed in or- der to decrease the number of biosensor properties. Sub- strate inhibition and interactions during biodegradation of pollutant mixtures is discussed by Okpokwasili et al. [6]. Multi-enz