Antioxidant attenuation of ROS-involved cytotoxicity induced by Paraquat on HL-60 cells英文文献资料.docVIP

Vol.2, No.3, 253-261 (2010) Health doi:10.4236/health.2010.23036 Antioxidant attenuation of ROS-involved cytotoxicity induced by Paraquat on HL-60 cells Wen-Hua Zhang, Yang Yang, Chang-Jun Lin, Qin Wang School of Life Sciences, Lanzhou University, Lanzhou, China; qwang@ Received 23 December 2009; revised 10 January 2010; accepted 14 January 2010. ABSTRACT 4’-dipyridyliuim, whose herbicidal property was reported in 1958. Since its toxicity is dosage-dependent, a wide spectrum of studies on PQ-induced toxicity had been conducted at various levels, aiming to standardize the safe dosage to minimize its toxicity to other untargeted organisms. Although an in vivo experiment upon the toxicity of PQ, which set up the rats and mouse as study objects and factored into the acute and chronic toxicity as well as teratogenicity and mutagenicity, was conducted to have claimed that PQ would be safe if used following the recommended use instruction, the hard-to-control ma- nipulation of use in practice and differentiated suscepti- bility of animal species necessitate the investigations of underlying mechanism of PQ-induce cytotoxicity. More- over, advanced techniques had already been employed to identify effective candidate molecules to reduce PQ- induced toxicity [3]. PQ is biologically active after it has been sprayed in the field. It’s either strongly bound to soil particles or de- composed into a non-toxic form by soil bacterial and sunlight [4]. However, active form of PQ is highly toxic to humans and many cases of acute poisoning and death had been reported over the past few decades [5-9]. The most frequent routes of exposure to PQ, either acciden- tally or intentionally, in humans and animals are by in- gestion or through direct skin contact. Regardless of the well-tuned administration of circulation and body-defense systems, PQ could be rapidly distributed in most tissues, with the highe