Basic Research – Significance of Detection and Clinical Impact of Candida albicans in Non-Immunosuppressed Patients英文文献资料.docVIP

Pharmacology Pharmacy, 2011, 2, 354-360 doi:10.4236/pp.2011.24046 Published Online October 2011 (http://www.SciRP.org/journal/pp) Basic Research―Significance of Detection and Clinical Impact of Candida albicans in Non-Immunosuppressed Patients Petra Heizmann , Frank Klefisch , Wolfgang R. Heizmann 1 2 3 1 St. Wolfgang Clinic, Internal Medicine, Bad Griesbach, Germany; Paulinenhaus Krankenanstalt e.V., Berlin, Germany; Centre for 2 3 Medical Microbiology and Infectiology, Berlin, Germany. Email: wrheizmann@ Received May 15 , 2011; revised September 14 , 2011; accepted September 30 , 2011. th th th ABSTRACT Background: The clinical significance of the detection of Candida albicans on mucous membranes of the respiratory or intestinal tract from patients in intensive care units is still not finally clarified. Many patients reveal colonization, al- though, despite increased risk, there are only a few invasive infections detectable. Therefore, antimycotic therapy in this setting is strongly discouraged. In reality, however, many patients receive antimycotics as a pre-emptive therapy. To elucidate this point, a literature research was performed. Results: In the light of new results on the pathogenicity of C. albicans, the recommendation not to treat should be discussed anew. Without becoming invasive, C. albicans influences the immune system negatively in an anti-inflammatory sense (Th2) by means of at least two distinct mechanisms [action on toll like receptors (TLR), production of farnesol], which will be discussed. Conclusion: It is believed that patients in the phase of CA