Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test英文文献资料.docVIP

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Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test英文文献资料.doc

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Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test英文文献资料

HindawiPublishingCorporation InternationalJournalofBiomaterials Volume2011,ArticleID424571,6pages doi:10.1155/2011/424571 ResearchArticle BiodegradablePolymersInduceCD54onTHP-1Cellsin SkinSensitizationTest YeonSukJung,1,2ReikoKato,1andToshieTsuchiya 1,3 1 2 3 DivisionofMedicalDevices,NationalInstituteofHealthSciences,1-18-1Kamiyoga,Setagaya-ku,Tokyo158-8501,Japan DivisionofUrology,CancerInstituteofNewJersey,RobertWoodJohnsonMedicalSchool,NewBrunswick,NJ08901,USA MedicalCenterforTranslationalResearch,OsakaUniversityHospital,2-15Yamadaoka,Suita,Osaka565-0871,Japan CorrespondenceshouldbeaddressedtoToshieTsuchiya,tsutoshi2005@ Received5January2011;Revised18May2011;Accepted8June2011 AcademicEditor:RosalindLabow Copyright?2011YeonSukJungetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Currently,nonanimalmethodsofskinsensitizationtestingforvariouschemicals,biodegradablepolymers,andbiomaterialsare beingdevelopedinthehopeofeliminatingtheuseofanimals.Thehumancelllineactivationtest(h-CLAT)isaskinsensitization assessmentthatmimicsthefunctionsofdendriticcells(DCs).DCsarespecializedantigen-presentingcells,andtheyinteractwith TcellsandBcellstoinitiateimmuneresponses.PhenotypicchangesinDCs,suchastheproductionofCD86andCD54and internalizationofMHCclassIImolecules,havebecomefocalpointsoftheskinsensitizationtest.Inthisstudy,weusedh-CLATto assessthee?ectsofbiodegradablepolymers.Theresultsshowedthatseveralbiodegradablepolymersincreasedtheexpressionof CD54,andtherelativeskinsensitizingabilitiesofbiodegradablepolymerswerePLLG(75:25)PLLC(40:60)PLGA(50:50) PCG(50:50).Theseresultsmaycontributetothecreationofnewguidelinesfortheuseofbiodegradablepolymersinsca?olds orallergenichazards. 1.Introduction to the secondary lymphoid organs to present na¨?ve T cells [17]. Then, immature DCs mature and intercellular adhesion molecules, costimulatory molecules, a