Blood Glucose Prediction Using Artificial Neural Networks Trained with the AIDA Diabetes Simulator A Proof-of-Concept Pilot Study英文文献资料.docVIP

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Blood Glucose Prediction Using Artificial Neural Networks Trained with the AIDA Diabetes Simulator A Proof-of-Concept Pilot Study英文文献资料.doc

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Blood Glucose Prediction Using Artificial Neural Networks Trained with the AIDA Diabetes Simulator A Proof-of-Concept Pilot Study英文文献资料

HindawiPublishingCorporation JournalofElectricalandComputerEngineering Volume2011,ArticleID681786,11pages doi:10.1155/2011/681786 ResearchArticle BloodGlucosePredictionUsingArti?cialNeural NetworksTrainedwiththeAIDADiabetesSimulator: AProof-of-ConceptPilotStudy GavinRobertson, EldonD.Lehmann, 1 2WilliamSandham,1,3andDavidHamilton4 1 2 BioengineeringDepartment,UniversityofStrathclyde,WolfsonBuilding,106Rottenrow,GlasgowG40NW,UK DepartmentofImaging,CMRU,ImperialCollegeofScience,TechnologyandMedicine,RoyalBromptonHospital, SydneyStreet,LondonSW36NP,UK 3 4 Scotsig,40WestbourneGardens,GlasgowG129PF,UK AteedaLimited,CBCHouse,24CanningStreet,EdinburghEH38EG,UK CorrespondenceshouldbeaddressedtoWilliamSandham,w.sandham@scotsig.co.uk Received3November2010;Accepted18February2011 AcademicEditor:JohnWalsh Copyright?2011GavinRobertsonetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Diabetesmellitusisamajor,andincreasing,globalproblem.However,ithasbeenshownthat,throughgoodmanagementof blood glucose levels (BGLs), the associated and costly complications can be reduced signi?cantly. In this pilot study, Elman recurrentarti?cialneuralnetworks(ANNs)wereusedtomakeBGLpredictionsbasedonahistoryofBGLs,mealintake,and insulininjections.Twenty-eightdatasets(fromasinglecasescenario)werecompiledfromthefreewaremathematicaldiabetes simulator,AIDA.Itwasfoundthatthemostaccuratepredictionsweremadeduringthenocturnalperiodofthe24hourdaily cycle.Theaccuracyofthenocturnalpredictionswasmeasuredastherootmeansquareerrorover?vetestdays(RMSE5day )not usedduringANNtraining.ForBGLpredictionsofupto1houraRMSE5dayof(±SD)0.15±0.04mmol/Lwasobserved.ForBGL predictionsupto10hours,aRMSE5dayof(±SD)0.14±0.16mmol/Lwasobserved.Futureresearchwillinvestigateawiderrange ofAIDAcasescenarios,real-patientdata,anddatarelatingtootherfactorsin?uencingBG