Burkholderia cepacia Complex Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants英文文献资料.docVIP

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Burkholderia cepacia Complex Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants英文文献资料.doc

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Burkholderia cepacia Complex Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants英文文献资料

HindawiPublishingCorporation InternationalJournalofMicrobiology Volume2011,ArticleID607575,9pages doi:10.1155/2011/607575 ReviewArticle BurkholderiacepaciaComplex:EmergingMultihost PathogensEquippedwithaWideRangeofVirulence FactorsandDeterminants S′?lviaA.Sousa,ChristianG.Ramos,andJorgeH.Leit?ao IBB-InstituteforBiotechnologyandBioengineering,CentreforBiologicalandChemicalEngineering, InstitutoSuperiorT′ecnico,Av.RoviscoPais,1049-001Lisboa,Portugal CorrespondenceshouldbeaddressedtoJorgeH.Leit?ao,jorgeleitao@ist.utl.pt Received11May2010;Accepted2June2010 AcademicEditor:MaxTeplitski Copyright?2011S′?lviaA.Sousaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. TheBurkholderiacepaciacomplex(Bcc)comprisesatleast17closely-relatedspeciesoftheβ-proteobacteriasubdivision,widely distributedinnaturalandman-madeinhabitats.Bccbacteriaareendowedwithanextraordinarymetabolicdiversityandemerged inthe1980saslife-threateninganddi?cult-to-treatpathogensamongpatientssu?eringfromcystic?brosis.Morerecently,these bacteriabecamerecognizedasathreattohospitalizedpatientssu?eringfromotherdiseases,inparticularoncologicalpatients.In thepresentpaper,wereviewtheseandothertraitsofBccbacteria,aswellassomeofthestrategiesusedtoidentifyandvalidate thevirulencefactorsanddeterminantsusedbythesebacteria.Theidenti?cationandcharacterizationofthesevirulencefactorsis expectedtoleadtothedesignofnoveltherapeuticstrategiesto?ghttheinfectionscausedbytheseemergentmultidrugresistant humanpathogens. 1.TheBurkholderiacepacia Complex—AnOverview somestrains topromote plantgrowth,bacteriaoftheBcc haveattractedsigni?cantcommercialinterestasbiocontrol, bioremediation,andplant-growthpromotingagents,mainly due to their ability to colonize the rhizosphere of several cropsofeconomicalinterest,likecorn,maize,rice,pea,and sun?ower[2].However,thesebacteriahavealsoemergedas important human